![]() ![]() To explain these pathophysiological features and discuss the ventilatory strategy during the late phase of severe ARDS in COVID-19 patients, we first used a metabolic module on a General Electric R860 ventilator (Engstrom Carestation GE Healthcare, USA) to monitor parameters related to gas metabolism, lung mechanics and physiological dead space in two COVID-19 patients. However, the underlying mechanics remain unclear. Actually, we newly observed that some mechanically ventilated COVID-19 patients recovering from severe ARDS (more than 14 days after invasive ventilation) often experienced evidently gradual increases in CO 2 retention and minute ventilation. Recently, several articles have mentioned that the early acute respiratory distress syndrome (ARDS) caused by COVID-19 significantly differ from those of ARDS due to other causes. 45: 227–243.An ongoing outbreak of coronavirus disease 2019 (COVID-19) is spreading globally. ![]() The physiologic basis of pulmonary gas exchange: implications for clinical interpretation of arterial blood gases. Philadelphia: Lippincott Williams & Wilkins. ![]() ![]() In: Lippincott's Pathophysiology Series: Pulmonary Pathophysiology. “Gas transport to and from peripheral tissues”. In: Fishman's Pulmonary Diseases and Disorders, edited by MA, Grippi (editor-in-chief), JA, Elias, JA, Fishman, RM, Kotloff, AI, Pack, RM, Senior (editors). “Clinical presentations: gas exchange and transport”. ![]()
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